Protein Details: Cation channel sperm-associated protein 4

Protein ID

ICDB_Pro_1156

Protein Name

Cation channel sperm-associated protein 4

Gene Name

CATSPER4

Organism

Homo sapiens (Human)

Length

472 amino acids

AlphaFoldDB

AF-Q7RTX7-F1-model_v4.pdb

Function

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization; such as sperm hyperactivation; acrosome reaction and chemotaxis towards the oocyte.

Sequence

MRDNEKAWWQQWTSHTGLEGWGGTQEDRMGFGGAVAALRGRPSPLQSTIHESYGRPEEQVLINRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPLAGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLNRRSSTSGSLETTSSKDIRQMSQQQDLLSALVSMEKVHDSSSQILLKKHKSSH

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Placental Choriocarcinoma and Ceroid Lipofuscinosis;Neuronal

Location

Testis-specific

DOI ID

10.1038/nature04727; 10.1101/gr.2596504; 10.1186/1477-7827-1-53; 10.1093/molehr/gam009; 10.1038/nature09769; 10.1038/nature09767; 10.1126/science.aad6887

RefSeq

NP_937770.1 [Q7RTX7-1]